Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.

@article{Kantola1997FoldingOT,
  title={Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.},
  author={Jaana Kantola and Gloria Blanco and Anne Hautala and Tero Kunnari and juha. hakala and Carmen M{\'e}ndez and Kristiina Ylihonko and Pekka Maentsaelae and Jose Fern{\'a}ndez Salas},
  journal={Chemistry & biology},
  year={1997},
  volume={4 10},
  pages={751-5}
}
BACKGROUND Mithramycin, nogalamycin and aclacinomycins are aromatic polyketide antibiotics that exhibit antitumour activity. The precursors of these antibiotics are formed via a polyketide biosynthetic pathway in which acetate (for mithramycinone and nogalamycinone) or propionate (for aklavinone) is used as a starter unit and nine acetates are used as extender units. The assembly of building blocks is catalyzed by the minimal polyketide synthase (PKS). Further steps include regiospecific… CONTINUE READING