Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

Abstract

Folds in the cerebral cortex in mammals are believed to be key structures for accommodating increased cortical neurons in the cranial cavity. However, the mechanisms underlying cortical folding remain largely unknown, mainly because genetic manipulations for the gyrencephalic brain have been unavailable. By combining in utero electroporation and the CRISPR… (More)
DOI: 10.1016/j.celrep.2017.08.024

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@article{Shinmyo2017FoldingOT, title={Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.}, author={Yohei Shinmyo and Yukari Terashita and Tung Anh Dinh Duong and Toshihide Horiike and Muneo Kawasumi and Kazuyoshi Hosomichi and Atsushi Tajima and Hiroshi Kawasaki}, journal={Cell reports}, year={2017}, volume={20 9}, pages={2131-2143} }