Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.

@article{Senes2004FoldingOH,
  title={Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.},
  author={Alessandro Senes and Donald Engel and William F. DeGrado},
  journal={Current opinion in structural biology},
  year={2004},
  volume={14 4},
  pages={465-79}
}
Helical integral membrane proteins share several structural determinants that are widely conserved across their universe. The discovery of common motifs has furthered our understanding of the features that are important to stability in the membrane environment, while simultaneously providing clues about proteins that lack high-resolution structures. Motif analysis also helps to target mutagenesis studies, and other experimental and computational work. Three types of transmembrane motifs have… CONTINUE READING

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