Folding of active calcium channel beta(1b) -subunit by size-exclusion chromatography and its role on channel function.

@article{Neely2004FoldingOA,
  title={Folding of active calcium channel beta(1b) -subunit by size-exclusion chromatography and its role on channel function.},
  author={A. D. Neely and Jennie Garcia-Olivares and Stephan Voswinkel and Hannelore Horstkott and P. Rodrı́guez Hidalgo},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 21},
  pages={
          21689-94
        }
}
Voltage-gated calcium channels mediate the influx of Ca(2+) ions into eukaryotic cells in response to membrane depolarization. They are hetero-multimer membrane proteins formed by at least three subunits, the poreforming alpha(1)-subunit and the auxiliary beta- and alpha(2)delta-subunits. The beta-subunit is essential for channel performance because it regulates two distinct features of voltage-gated calcium channels, the surface expression and the channel activity. Four beta-subunit genes have… CONTINUE READING

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