Folding of CFTR is predominantly cotranslational.

  title={Folding of CFTR is predominantly cotranslational.},
  author={Bertrand Kleizen and Thijs van Vlijmen and Hugo R. de Jonge and Ineke Braakman},
  journal={Molecular cell},
  volume={20 2},
The folding process for newly synthesized, multispanning membrane proteins in the endoplasmic reticulum (ER) is largely unknown. Here, we describe early folding events of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC-transporter family. In vitro translation of CFTR in the presence of semipermeabilized cells allowed us… CONTINUE READING