Folding delay and structural perturbations caused by type IV collagen natural interruptions and nearby Gly missense mutations.


The standard collagen triple helix requires Gly as every third residue in the amino acid sequence, yet all nonfibrillar collagens contain sites where this repeating pattern is interrupted. To explore the effects of such natural interruptions on the triple helix, a 4- or 15-residue sequence from human basement membrane type IV collagen was introduced between… (More)
DOI: 10.1074/jbc.M111.269084