Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

Abstract

Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to undergo a conformational shift postulated to inhibit translation. Using optical tweezers (OT) and steered molecular… (More)
DOI: 10.7554/eLife.22883

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Cite this paper

@inproceedings{Le2017FoldingBO, title={Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch}, author={My-Tra Le and Wojciech Kasprzak and Taejin Kim and Feng Gao and Megan Y. L. Young and Xuefeng Yuan and Bruce A. Shapiro and Joonil Seog and Anne E Simon}, booktitle={eLife}, year={2017} }