Folding and unfolding of a photoswitchable peptide from picoseconds to microseconds.

@article{Ihalainen2007FoldingAU,
  title={Folding and unfolding of a photoswitchable peptide from picoseconds to microseconds.},
  author={Janne Ihalainen and Jens Bredenbeck and Rolf Pfister and Jan Helbing and Lei Chi and Ivo H M van Stokkum and G. Andrew Woolley and Peter Hamm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={
          5383-8
        }
}
Using time-resolved IR spectroscopy, we monitored the kinetics of folding and unfolding processes of a photoswitchable 16-residue alanine-based alpha-helical peptide on a timescale from few picoseconds to almost 40 micros and over a large temperature range (279-318 K). The folding and unfolding processes were triggered by an ultrafast laser pulse that isomerized the cross linker within a few picoseconds. The main folding and unfolding times (700 ns and 150 ns, respectively, at room temperature… CONTINUE READING

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