Folding and assembly of viral membrane proteins.

  title={Folding and assembly of viral membrane proteins.},
  author={Robert W. Doms and Robert A. Lamb and John K. Rose and Ari Helenius},
  volume={193 2},
It is now clear that folding in the ER is a dynamic, energy-driven process involving a host of cellular folding enzymes and molecular chaperones (see Fig. 1). Within this high-capacity folding environment, nascent molecules fold quickly and efficiently, while misfolded proteins are recognized and retained, being either degraded or rescued. The quality control mechanisms which account for this selective retention are most likely redundant and general in nature--an almost innumerable number of… CONTINUE READING