Folding aggregated proteins into functionally active forms.

@article{Swietnicki2006FoldingAP,
  title={Folding aggregated proteins into functionally active forms.},
  author={Wieslaw Swietnicki},
  journal={Current opinion in biotechnology},
  year={2006},
  volume={17 4},
  pages={367-72}
}
The successful expression and purification of proteins in an active form is essential for structural and biochemical studies. With rapid advances in genome sequencing and high-throughput structural biology, an increasing number of proteins are being identified as potential drug targets but are difficult to obtain in a form suitable for structural or biochemical studies. Although prokaryotic recombinant expression systems are often used, proteins obtained in this way are typically found to be… CONTINUE READING

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