Folding a nonbiological polymer into a compact multihelical structure.

@article{Lee2005FoldingAN,
  title={Folding a nonbiological polymer into a compact multihelical structure.},
  author={Byoung-Chul Lee and Ronald N. Zuckermann and Ken A. Dill},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 31},
  pages={10999-1009}
}
The only molecules that are currently known to fold into unique three-dimensional conformations and perform sophisticated functions are biological polymers - proteins and some RNA molecules. Our aim is to create a nonbiological sequence-specific polymer that folds in aqueous solution. Toward that end, we synthesized sequence-specific 30mer, 45mer, and 60mer peptoid oligomers (N-substituted glycine polymers) consisting of 15mer units we chained together by disulfide and oxime linkages to mimic… CONTINUE READING

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Toward that end , we synthesized sequence - specific 30mer , 45mer , and 60mer peptoid oligomers ( N - substituted glycine polymers ) consisting of 15mer units we chained together by disulfide and oxime linkages to mimic the helical bundle structures commonly found in proteins .
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