Folding DNA into twisted and curved nanoscale shapes.

@article{Dietz2009FoldingDI,
  title={Folding DNA into twisted and curved nanoscale shapes.},
  author={Hendrik Dietz and Shawn M. Douglas and William M. Shih},
  journal={Science},
  year={2009},
  volume={325 5941},
  pages={725-30}
}
We demonstrate the ability to engineer complex shapes that twist and curve at the nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to their helical axes. Targeted insertions and deletions of base pairs cause the DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 234 extracted citations

Engineered nanoparticles for targeted drug delivery

2012 IEEE Long Island Systems, Applications and Technology Conference (LISAT) • 2012
View 5 Excerpts
Highly Influenced

DNA-Based Enzyme Reactors and Systems

Nanomaterials • 2016
View 6 Excerpts
Highly Influenced

A Theoretical and Experimental Study of DNA Self-assembly by Harish Chandran

Harish Chandran, Supervisor Thomas LaBean Chris Dwyer Kamesh Munagala
2012
View 4 Excerpts
Highly Influenced

Structural DNA Nanotechnology: From Design to Applications

International journal of molecular sciences • 2012
View 3 Excerpts
Highly Influenced

Recent progress in DNA origami technology.

Current protocols in nucleic acid chemistry • 2011
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…