Folding DNA into twisted and curved nanoscale shapes.

  title={Folding DNA into twisted and curved nanoscale shapes.},
  author={Hendrik Dietz and Shawn M. Douglas and William M. Shih},
  volume={325 5941},
We demonstrate the ability to engineer complex shapes that twist and curve at the nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to their helical axes. Targeted insertions and deletions of base pairs cause the DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as… CONTINUE READING
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