Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration

  title={Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration},
  author={Dominique T. Capraro and Shachi Gosavi and Melinda Roy and Jos{\'e} N. Onuchic and Patricia Ann Jennings},
  booktitle={PloS one},
Interleukin-1β (IL-1β) is the cytokine crucial to inflammatory and immune response. Two dominant routes are populated in the folding to native structure. These distinct routes are a result of the competition between early packing of the functional loops versus closure of the β-barrel to achieve efficient folding and have been observed both experimentally and computationally. Kinetic experiments on the WT protein established that the dominant route is characterized by early packing of… CONTINUE READING
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