Fold-recognition detects an error in the Protein Data Bank

  title={Fold-recognition detects an error in the Protein Data Bank},
  author={Janusz M. Bujnicki and Leszek Rychlewski and Daniel Fischer},
  volume={18 10},
Determining the 3D-structure of a protein by means of X-ray crystallography, requires the fitting of the amino acid sequence into an electron-density map. This can be a difficult, time-consuming task if the map is of low resolution, showing little data for the side-chains. Here we show how fold recognition allowed us to detect an error in a recently deposited PDB entry, and propose a method that can be of aid in the fitting of a sequence into a lowresolution electron-density map. The described… CONTINUE READING


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Combining sequence derived properties with evolutionary information

  • D. Fischer
  • Proc . Pac . Symp . Biocomput .
  • 2000
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