Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)

@article{Hooijberg2014FolatesPC,
  title={Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)},
  author={Jan Hendrik Hooijberg and Gerrit Jansen and Ietje Kathmann and Rob Pieters and Adrie C. Laan and Ina van Zantwijk and Gertjan J. L. Kaspers and Godefridus J. Peters},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={73},
  pages={911-917}
}
  • Jan Hendrik Hooijberg, Gerrit Jansen, +5 authors Godefridus J. Peters
  • Published in
    Cancer Chemotherapy and…
    2014
  • Medicine, Biology
  • Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs. As a model system, we used the human ovarian carcinoma cell line 2008wt, and its stably MRP1/ABCC1-transfected subline 2008/MRP1. These cell types have a… CONTINUE READING

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