Folates and the fetus.

  title={Folates and the fetus.},
  author={T. K. A. B. Eskes},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  volume={71 2},
  • T. K. A. B. Eskes
  • Published 1997 in
    European journal of obstetrics, gynecology, and…
It is proven that folic acid supplied in the periconceptional period can lower the recurrence and occurrence rate of neural tube defects (NTDs). Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHF-R)). Reduced activity of the folate methylation cycle seems to be an attractive working hypothesis in the aetiology of… CONTINUE READING