Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet

@article{Li2018FolateTO,
  title={Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet},
  author={Jian Li and Yong-Ping Lu and Oleg Tsuprykov and Ahmed A. Hasan and Christoph Reichetzeder and Mei Tian and Xiao Li Zhang and Qin Zhang and Guo-Ying Sun and Jingli Guo and Mohamed M. S. Gaballa and Xiao-Ning Peng and Ge Lin and Berthold Hocher},
  journal={Diabetologia},
  year={2018},
  volume={61},
  pages={1862-1876}
}
Aims/hypothesisPaternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy.MethodsMale F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After… CONTINUE READING
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