Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.

@article{Kooistra2013FolateTI,
  title={Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.},
  author={Megan Kooistra and Jacquetta M. Trasler and Jay M Baltz},
  journal={Biology of reproduction},
  year={2013},
  volume={89 3},
  pages={63}
}
Endogenous folate stores are required in preimplantation embryos of several species, but how folates are accumulated and whether they can be replenished has not been determined. Folates are generally taken up into cells by specific transporters, mainly the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptors FOLR1 and FOLR2. Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed… CONTINUE READING
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