Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis.

@article{Turk2002FolatetargetedIO,
  title={Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis.},
  author={Mary Jo Turk and Gert J. Breur and William R. Widmer and Chrystal Mary Paulos and Le-cun Xu and Lee Ann Grote and Philip S Low},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 7},
  pages={
          1947-55
        }
}
OBJECTIVE To determine whether overexpression of the high-affinity folate receptor (FR) on activated macrophages can be exploited to selectively target imaging agents to sites of inflammation in rats with adjuvant-induced arthritis (AIA). METHODS Folic acid was conjugated to a (99m)Tc chelator (the complex termed EC20), and its distribution was visualized using gamma scintigraphy in healthy rats, rats with AIA, and arthritic rats that had been depleted of macrophages. To confirm that uptake… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 82 CITATIONS

FILTER CITATIONS BY YEAR

2003
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 5 Citations per year over the last 3 years

  • 50% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Similar Papers

Loading similar papers…