Folate supplementation in methotrexate-treated rheumatoid arthritis patients.

  title={Folate supplementation in methotrexate-treated rheumatoid arthritis patients.},
  author={Kitty Stewart and Alec Mackenzie and John D Clough and William Samuel Wilke},
  journal={Seminars in arthritis and rheumatism},
  volume={20 5},
Two hundred rheumatoid arthritis (RA) patients taking low dose methotrexate (MTX) were evaluated for adverse effects. During a mean follow up of 41.5 months, the mean cell volume (MCV) was elevated at some time during the course of treatment in 42 patients. The MCV was normal in the remaining 158 patients. One hundred ninety-eight patients were treated simultaneously with oral folic acid. With the exception of heartburn, which was seen more often in the high MCV group, there was no difference… CONTINUE READING

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