Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.

@article{Morgan1987FolateSO,
  title={Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.},
  author={Sarah L. Morgan and Joseph E. Baggott and M. Altz-Smith},
  journal={Arthritis and rheumatism},
  year={1987},
  volume={30 12},
  pages={1348-56}
}
The folate status of 29 healthy control subjects, 16 rheumatoid arthritis (RA) patients taking methotrexate (MTX), and 20 RA patients who were not being treated with MTX was estimated by an assay of the folate-dependent enzymatic synthesis of serine from formate and glycine, which is termed the C1 index. Analysis of variance demonstrated that the specific activity of the enzyme system in lymphocytes was significantly lower in the MTX-treated group, with an activity approximately one-half that… CONTINUE READING

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