Folate status and neural tube defects

@article{Molloy1999FolateSA,
  title={Folate status and neural tube defects},
  author={Anne M. Molloy and James L. Mills and Peadar N. Kirke and Donald G. Weir and John M. Scott},
  journal={BioFactors},
  year={1999},
  volume={10}
}
Periconceptional folic acid supplementation prevents approximately 70% of neural tube defects (NTDs). While most women carrying affected fetuses do not have deficient blood folate levels, the risk of having an NTD affected child is inversely correlated with pregnancy red cell folate levels. Current research is focused on the discovery of genetic abnormalities in folate related enzymes which might explain the role of folate in NTD prevention. The first candidate gene to emerge was the C677T… 

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References

SHOWING 1-10 OF 18 REFERENCES

Homocysteine metabolism in pregnancies complicated by neural-tube defects

Folate levels and neural tube defects. Implications for prevention.

Using data from a recent case-control study, a woman's risk of having a child with a neural tube defect (NTD) was found to be associated with early pregnancy red cell folate levels in a continuous

Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.

TLDR
It is shown that homozygosity for the C677T MTHFR variant cannot account for reduced blood folate levels in many NTD-affected mothers, and a strategy of genetic screening of all childbearing women for this variant would be ineffective as a method of primary prevention of NTDs.

5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.

TLDR
Preliminary data suggest that the 677C-->T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD.

Maternal vitamin levels during pregnancies producing infants with neural tube defects.

Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.

TLDR
Plasma folate and plasma B12 were independent risk factors for NTDs, suggesting that the enzyme methionine synthase is involved directly or indirectly in the aetiology.

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects.

Serum folate and vitamin B12 concentrations in early pregnancy were compared for 32 mothers with pregnancies affected by neural tube defects and 395 randomly selected pregnant control women from the

Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.