Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.

@article{PuigKrger2009FolateRB,
  title={Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.},
  author={Amaya Puig-Kr{\"o}ger and Elena Sierra-Filardi and {\'A}ngeles Dom{\'i}nguez-Soto and Rafael Samaniego and Mar{\'i}a Teresa Corcuera and Fernando G{\'o}mez-Aguado and M. Venkata Ratnam and Paloma S{\'a}nchez-Mateos and {\'A}ngel L Corb{\'i}},
  journal={Cancer research},
  year={2009},
  volume={69 24},
  pages={9395-403}
}
Macrophage activation comprises a continuum of functional states critically determined by cytokine microenvironment. Activated macrophages have been functionally grouped according to their response to pro-Th1/proinflammatory stimuli [lipopolysaccharide, IFNgamma, granulocyte macrophage colony-stimulating factor (GM-CSF); M1] or pro-Th2/anti-inflammatory stimuli [interleukin (IL)-4, IL-10, M-CSF; M2]. We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for… CONTINUE READING

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Targeting tumorassociated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor

  • T Nagai, TanakaM, Y Tsuneyoshi
  • β. Cancer Immunol Immunother
  • 2009
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