Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.

@article{Ramaekers2007FolateRA,
  title={Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits.},
  author={Vincent Th. Ramaekers and Nenad Blau and Jeffrey M. Sequeira and M-C L Nassogne and Edward V Quadros},
  journal={Neuropediatrics},
  year={2007},
  volume={38 6},
  pages={276-81}
}
Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with early-onset low-functioning autism with or without neurological deficits, were evaluated for serum folate, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies of the blocking type to determine the significance of folate receptor (FR) autoantibodies with respect… CONTINUE READING

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