Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.

@article{Krull2008FolatePG,
  title={Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.},
  author={Kevin R Krull and Pim Y Brouwers and Neelam Jain and Linna Zhang and Lisa R. Bomgaars and Zoann Dreyer and Donald Mahoney and Sarah Bottomley and M. Fatih Okcu},
  journal={The Journal of pediatrics},
  year={2008},
  volume={152 1},
  pages={101-5}
}
OBJECTIVE To test the hypothesis that 5,10-methylenetetrahydroreductase (MTHFR) polymorphisms can partially explain the individual variation in developing attention-deficit/hyperactivity disorder (ADHD) after acute lymphoblastic leukemia (ALL) therapy. STUDY DESIGN Parents of 48 survivors of childhood ALL completed a clinical diagnostic process to identify subtypes of ADHD. Genotyping was performed with peripheral blood DNA for MTHFR (C677T and A1298C) polymorphisms. RESULTS Eleven of the… CONTINUE READING
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