Folate metabolism as a source of molecular targets for antimalarials.

Abstract

Folate metabolism of the malaria parasites provides two targets for current antimalarials: dihydrofolate reductase and dihydropteroate synthase. Dihydrofolate reductase inhibitors have been used as antimalarials over the past few decades, often in combination with dihydropteroate synthase inhibitors. Resistance to these antifolate drugs developed through… (More)

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Cite this paper

@article{Yuthavong2006FolateMA, title={Folate metabolism as a source of molecular targets for antimalarials.}, author={Yongyuth Yuthavong and Sumalee Kamchonwongpaisan and Ubolsree Leartsakulpanich and Penchit Chitnumsub}, journal={Future microbiology}, year={2006}, volume={1 1}, pages={113-25} }