Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case–control study

@article{Gast2007FolateMG,
  title={Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case–control study},
  author={Andreas Gast and Justo Lorenzo Bermejo and Thomas Flohr and Martin Stanulla and Barbara Burwinkel and Martin Schrappe and Claus Rainer Bartram and Kari Hemminki and Rajiv Kumar},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={320-325}
}
We genotyped six folate metabolic pathway genes for 11 polymorphisms in 460 cases of childhood acute lymphoblastic leukemia (ALL) and 552 ethnically matched controls. None of the polymorphisms except the 66A>G (I22M) in the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene showed any effect on disease risk. The carriers of the G-allele were associated with a marginal decreased risk of ALL (gender-adjusted global P=0.03; multiple-testing corrected P=0.25). Analysis of… CONTINUE READING

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Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia

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