Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.

@article{Laanpere2010FolatemediatedOM,
  title={Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.},
  author={Margit Laanpere and Signe Altm{\"a}e and Anneli Stavreus-Evers and Torbj{\"o}rn K. Nilsson and Agneta Yngve and Andres Salumets},
  journal={Nutrition reviews},
  year={2010},
  volume={68 2},
  pages={
          99-113
        }
}
This review summarizes current knowledge of the effect of folate-mediated one-carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with lower ovarian reserves… CONTINUE READING
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