Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.

@article{Larsson2006FolateIM,
  title={Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.},
  author={Susanna C Larsson and Edward L. Giovannucci and Alicja Wolk},
  journal={Gastroenterology},
  year={2006},
  volume={131 4},
  pages={1271-83}
}
BACKGROUND & AIMS Increasing evidence suggests that a low folate intake and impaired folate metabolism may be implicated in the development of gastrointestinal cancers. We conducted a systematic review with meta-analysis of epidemiologic studies evaluating the association of folate intake or genetic polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, with risk of esophageal, gastric, or pancreatic cancer. METHODS A literature search was… CONTINUE READING
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