Folate in depression: efficacy, safety, differences in formulations, and clinical issues.

@article{Fava2009FolateID,
  title={Folate in depression: efficacy, safety, differences in formulations, and clinical issues.},
  author={Maurizio Fava and David Mischoulon},
  journal={The Journal of clinical psychiatry},
  year={2009},
  volume={70 Suppl 5},
  pages={12-7}
}
Supplementation with folate may help reduce depressive symptoms. Folate, a naturally occurring B vitamin, is needed in the brain for the synthesis of norepinephrine, serotonin, and dopamine. Three forms of folate are commonly used: folic acid, 5-methyltetrahydrofolate (5-MTHF) (also known as methylfolate and L-methylfolate), and folinic acid. Some forms may be more bioavailable than others in patients with a genetic polymorphism and in those who take particular medications or use alcohol. Folic… CONTINUE READING
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Folate supplementation: is it safe and effective?

The Journal of clinical psychiatry • 2009
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