Folate for Depressive Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials

  title={Folate for Depressive Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials},
  author={Matthew J. Taylor and Stuart Carney and Guy M. Goodwin and John R. Geddes},
  journal={Journal of Psychopharmacology},
  pages={251 - 256}
The objective of this review was to determine the effectiveness, adverse effects and acceptability of folate in the treatment of depression. Electronic databases (Cochrane Controlled Trials Register and the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register) and reference lists were searched, and authors, experts and pharmaceutical companies contacted to identify randomized controlled trials that compared treatment with folic acid or 5 ′-methyltetrahydrofolic… 

Figures and Tables from this paper

The effects of folic acid supplementation on depression in adults: a systematic review and meta-analysis of randomized controlled trials
Purpose This study aims, a systematic review and meta-analysis, to evaluate the effects of folic acid (folate) on patients with depression. Design/methodology/approach Related articles were found
Adjunctive folate for major mental disorders: A systematic review.
Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
The FolATED trial generated no evidence that folic acid was clinically effective or cost-effective in augmenting ADM, and the findings undermine treatment guidelines that advocate folic Acid for treating depression, and suggest future trials of methylfolate to augment ADM.
Complementary therapies for clinical depression: an overview of systematic reviews
The effects of all but two CAM treatments found in studies on clinical depressed patients based on low to very low quality of evidence have to be downgraded mostly due to avoidable methodological flaws of both the original RCTs and meta-analyses not following the Consolidated Standards of Reporting Trials and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
If folic acid is shown to improve the efficacy of antidepressants, then it will provide a safe, simple and cheap way of improving the treatment of depression in primary and secondary care.
Acid Folic Supplementation in Major Depressive Disorder Treatment: A Double-Blind Randomized Clinical Trial
Folic acid, when used as a complementary therapy, can improve a patient’s response to antidepressants used for the treatment of major depression.
Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments.
A literature review was conducted to examine the evidence for nutritional interventions in depression and found that more positive clinical trials were found to support adjuvant, rather than monotherapeutic, use of nutrients to treat depression.
Nutrient intakes and the common mental disorders in women.


Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
Folate, vitamin B12, and homocysteine in major depressive disorder.
Folate levels might be considered in the evaluation of depressed patients who do not respond to antidepressant treatment, consistent with findings linking low folate levels to poorer response to antidepressants.
Oral 5′-methyltetrahydrofolic acid in senile organic mental disorders with depression: Results of a double-blind multicenter study
5′-MTHF and TRZ are equally effective in improving depressive symptoms in patients with mild to moderate dementia and suggests that pharmacological doses of 5′- MTHF may exert psychotropic effects irrespective of folate status.
A controlled study of folate levels in Chinese inpatients with major depression in Hong Kong.
Folate concentration in Chinese psychiatric outpatients on long-term lithium treatment.
Folate deficiency in depressive illness.
Serum folate and vitamin B12 levels have been measured in 101 patients with depressive illness and patients with subnormal folate levels were found to have significantly higher depressive scores, and significantly lower validity scores on the Marke-Nyman Temperament Scale.
Depression and tetrahydrobiopterin: the folate connection.
Effect of folic acid and vitamin B12 deficiencies on 5‐hydroxyindoleacetic acid in human cerebrspinal fluid
Indoles were measured in cerebrospinal fluid from control patients, from patients suffering from folate deficiency, and from patients with vitamin B12 deficiency to indicate a close association between folate‐responsive neuropsychiatric symptoms and change in 5‐hydroxytryptamine metabolism in the central nervous system.
Red cell folate concentrations in psychiatric patients.