Folate for Depressive Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials

@article{Taylor2004FolateFD,
  title={Folate for Depressive Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials},
  author={Matthew J Taylor and S. Carney and G. Goodwin and J. Geddes},
  journal={Journal of Psychopharmacology},
  year={2004},
  volume={18},
  pages={251 - 256}
}
The objective of this review was to determine the effectiveness, adverse effects and acceptability of folate in the treatment of depression. Electronic databases (Cochrane Controlled Trials Register and the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register) and reference lists were searched, and authors, experts and pharmaceutical companies contacted to identify randomized controlled trials that compared treatment with folic acid or 5 ′-methyltetrahydrofolic… Expand
Systematic review and meta-analysis of randomized placebo-controlled trials of folate and vitamin B12 for depression
TLDR
The results of these meta-analyses suggest that treatment with folate and vitamin B12 does not decrease the severity of depressive symptoms over a short period of time, but may be helpful in the long-term management of special populations. Expand
Adjunctive folate for major mental disorders: A systematic review.
TLDR
A systematic review found adjunctive folate appeared to be effective and safe for MDD and bipolar manic episode, but it was not effective in treating schizophrenia. Expand
Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
TLDR
The FolATED trial generated no evidence that folic acid was clinically effective or cost-effective in augmenting ADM, and the findings undermine treatment guidelines that advocate folic Acid for treating depression, and suggest future trials of methylfolate to augment ADM. Expand
Complementary therapies for clinical depression: an overview of systematic reviews
TLDR
The effects of all but two CAM treatments found in studies on clinical depressed patients based on low to very low quality of evidence have to be downgraded mostly due to avoidable methodological flaws of both the original RCTs and meta-analyses not following the Consolidated Standards of Reporting Trials and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Expand
Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
TLDR
If folic acid is shown to improve the efficacy of antidepressants, then it will provide a safe, simple and cheap way of improving the treatment of depression in primary and secondary care. Expand
Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis
TLDR
Assessment of the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis found that for most of the substances, the available data is not yet sufficient or inconclusive. Expand
The association of folate and depression: A meta-analysis.
TLDR
It is found that individuals with depression have lower serum levels of folate and dietary folate intake than individuals without depression, and clinicians may wish to consider folate supplementation for patients with depression. Expand
Acid Folic Supplementation in Major Depressive Disorder Treatment: A Double-Blind Randomized Clinical Trial
TLDR
Folic acid, when used as a complementary therapy, can improve a patient’s response to antidepressants used for the treatment of major depression. Expand
Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments.
TLDR
A literature review was conducted to examine the evidence for nutritional interventions in depression and found that more positive clinical trials were found to support adjuvant, rather than monotherapeutic, use of nutrients to treat depression. Expand
The Correlation between Depression and Folate Deficiency
TLDR
Low folate and B12 serum levels seem to be associated with depression and there is a strong body of evidence suggesting the introduction of folate supplement in the prevention and treatment of depression at the population and individual levels. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
TLDR
Folic acid is a simple method of greatly improving the antidepressant action of fluoxetine and probably other antidepressants, but men require a higher dose of folic acid to achieve this than women, but more work is required to ascertain the optimum dose. Expand
Folate, vitamin B12, and homocysteine in major depressive disorder.
TLDR
Folate levels might be considered in the evaluation of depressed patients who do not respond to antidepressant treatment, consistent with findings linking low folate levels to poorer response to antidepressants. Expand
Oral 5′-methyltetrahydrofolic acid in senile organic mental disorders with depression: Results of a double-blind multicenter study
TLDR
5′-MTHF and TRZ are equally effective in improving depressive symptoms in patients with mild to moderate dementia and suggests that pharmacological doses of 5′- MTHF may exert psychotropic effects irrespective of folate status. Expand
A controlled study of folate levels in Chinese inpatients with major depression in Hong Kong.
TLDR
Patients' lower serum folate level was likely to be secondary to their depression but, being well in the normal range, should not have aggravated their depressive symptoms. Expand
Folate concentration in Chinese psychiatric outpatients on long-term lithium treatment.
TLDR
Among 46 Chinese and mostly manic-depressive outpatients attending a lithium clinic in Hong Kong, virtually no patients had low serum or erythrocyte folate, and recent evidence that folate at high concentrations enhances lithium prophylaxis is supported. Expand
Enhancement of recovery from psychiatric illness by methylfolate
TLDR
Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery and add to the evidence implicating disturbances of methylation in the nervous system in the biology of some forms of mental illness. Expand
Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
TLDR
Folic acid supplementation starting before pregnancy can now be firmly recommended for all women who have had an affected pregnancy, and public health measures should be taken to ensure that the diet of allWomen who may bear children contains an adequate amount of folic acid. Expand
Enhancement of recovery from psychiatric illness by methylfolate.
TLDR
Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery and added to the evidence implicating disturbances of methylation in the nervous system in the biology of some forms of mental illness. Expand
Folate deficiency in depressive illness.
TLDR
Serum folate and vitamin B12 levels have been measured in 101 patients with depressive illness and patients with subnormal folate levels were found to have significantly higher depressive scores, and significantly lower validity scores on the Marke-Nyman Temperament Scale. Expand
Depression and tetrahydrobiopterin: the folate connection.
TLDR
The data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in affective disorder patients on lithium therapy and control subjects, and a significant positive correlation was found between plasma folate and urinary biopterin. Expand
...
1
2
3
4
...