Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.

@article{Funk2014FolateDA,
  title={Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.},
  author={Ryan S. Funk and Leon van Haandel and J. Steven Leeder and Mara Becker},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 12},
  pages={
          3476-85
        }
}
  • Ryan S. Funk, Leon van Haandel, +1 author Mara Becker
  • Published in Arthritis & rheumatology 2014
  • Medicine
  • OBJECTIVE Folates exist as a fluctuating pool of polyglutamated metabolites that may serve as a clinical marker of methotrexate (MTX) activity. This study was undertaken to evaluate circulating folate content and folate polyglutamate distribution in juvenile idiopathic arthritis (JIA) patients and in a cell culture model based on MTX exposure and folate supply. METHODS Blood, plasma, and red blood cell (RBC) measurements of MTX and folates were obtained from previously published data sets and… CONTINUE READING
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