Folate deficiency increases postischemic brain injury.

@article{Endres2005FolateDI,
  title={Folate deficiency increases postischemic brain injury.},
  author={Matthias Endres and Michael Ahmadi and Inna I. Kruman and Detlev Biniszkiewicz and Andreas Meisel and Karen Gertz},
  journal={Stroke},
  year={2005},
  volume={36 2},
  pages={321-5}
}
BACKGROUND AND PURPOSE Folate deficiency and resultant hyperhomocysteinemia impair vascular function and increase stroke risk. We tested the hypothesis that folate deficiency and high homocysteine levels promote DNA damage and increase brain injury after cerebral ischemia/reperfusion. METHODS 129/Sv mice, uracil-DNA glycosylase-deficient (Ung-/-) mice, and Ung+/+ littermate mice were exposed to a folate-deficient diet for 3 months and then subjected to 30-minute middle cerebral artery (MCA… CONTINUE READING
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