Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.

@article{Leu2000FolateDD,
  title={Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.},
  author={Richard K Le Leu and Graeme P. Young and Graeme Howie McIntosh},
  journal={Journal of gastroenterology and hepatology},
  year={2000},
  volume={15 10},
  pages={1158-64}
}
BACKGROUND AND AIMS It has been suggested that a diminished folate status may enhance colorectal carcinogenesis by causing DNA hypomethylation. The aims of the present study were to assess the impact of different levels of folate depletion on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and DNA hypomethylation in the colon of male Sprague-Dawley rats. METHODS Rats, aged 4 weeks, were divided into four groups and were fed semipurified diets either containing adequate folate… CONTINUE READING