Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison

  title={Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison},
  author={Chantal Courtemanche and Arnold C. Huang and Ilan Elson-Schwab and Nicole Kerry and Bernice Y. Ng and Bruce N. Ames},
  journal={The FASEB Journal},
DNA double‐strand breaks, the most serious DNA lesion caused by ionizing radiation, are also caused by several vitamin or mineral deficiencies, such as for folate. Primary human lymphocytes were either irradiated or cultured at different levels of folate deficiency to assess cell proliferation, apoptosis, cell cycle, DNA breaks, and changes in gene expression. Both radiation and folate deficiency decreased cell proliferation and induced DNA breaks, apoptosis, and cell cycle arrest. Levels of… 

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