Folate-binding triggers the activation of folylpolyglutamate synthetase.

@article{Sun2001FolatebindingTT,
  title={Folate-binding triggers the activation of folylpolyglutamate synthetase.},
  author={Xueying Sun and Jennifer A Cross and Andrew L. Bognar and Edward N Baker and Clyde A. Smith},
  journal={Journal of molecular biology},
  year={2001},
  volume={310 5},
  pages={1067-78}
}
Folic acid is an essential vitamin for normal cell growth, primarily through its central role in one-carbon metabolism. Folate analogs (antifolates) are targeted at the same reactions and are widely used as therapeutic drugs for cancer and bacterial infections. Effective retention of folates in cells and the efficacy of antifolate drugs both depend upon the addition of a polyglutamate tail to the folate or antifolate molecule by the enzyme folylpolyglutamate synthetase (FPGS). The reaction… CONTINUE READING
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