Folate and homocysteine metabolism in copper-deficient rats.

  title={Folate and homocysteine metabolism in copper-deficient rats.},
  author={Tsunenobu Tamura and Kezhu Hong and Yoshiko Mizuno and Kelley E. Johnston and Carl L. Keen},
  journal={Biochimica et biophysica acta},
  volume={1427 3},
To investigate the effect of copper deficiency on folate and homocysteine metabolism, we measured plasma, red-cell and hepatic folate, plasma homocysteine and vitamin B-12 concentrations, and hepatic methionine synthase activities in rats. Two groups of male Sprague-Dawley rats were fed semi-purified diets containing either 0. 1 mg (copper-deficient group) or 9.2 mg (control group) of copper per kg. After 6 weeks of dietary treatment, copper deficiency was established as evidenced by markedly… CONTINUE READING
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