Folate and epigenetic mechanisms in neural tube development and defects

Abstract

Multiple genetic and epigenetic factors involved in central nervous system (CNS) development influence the incidence of neural tube defects (NTDs). The beneficial effect of periconceptional folic acid on NTD prevention denotes a vital role for the single-carbon biochemical pathway in NTD genesis. Indeed, NTDs are associated with polymorphisms in a diversity… (More)
DOI: 10.1007/s00381-013-2162-0

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