Folate and Homocysteine in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease or Dementia: A Case Control Study

@article{Smach2011FolateAH,
  title={Folate and Homocysteine in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease or Dementia: A Case Control Study},
  author={Mohamed ali Smach and Nelly Jacob and J. L. Golmard and Bassem Charfeddine and Turkia M Lammouchi and Leila Ben Othman and Hedi Dridi and Soufien Bennamou and Khalifa Limem},
  journal={European Neurology},
  year={2011},
  volume={65},
  pages={270 - 278}
}
Background: Amyloid deposition in the brain is an early event in Alzheimer’s disease (AD), but a dysfunction of the blood-brain barrier or a disturbance in the metabolism of folate and homocysteine (Hcy) may affect the development of dementia. We investigated if the concentrations of folate and Hcy would be modified in cerebrospinal fluid (CSF) of clinically diagnosed AD patients. Methods: We included 70 AD patients, 33 patients with another type of dementia (nAD) and 30 age-matched control… 
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