Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas.

@article{Cho2019FolateRN,
  title={Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas.},
  author={Steve S Cho and Ryan Zeh and John T. Pierce and Jun Han Jeon and MacLean P Nasrallah and Nithin D. Adappa and James N. Palmer and Jason G. Newman and Caitlin White and Julia Kharlip and Peter J. Snyder and Philip S Low and Sunil Singhal and Michael Grady and John Y. K. Lee},
  journal={Operative neurosurgery},
  year={2019},
  volume={16 1},
  pages={
          59-70
        }
}
BACKGROUND Surgical resection is the primary treatment for nonfunctional (NF) pituitary adenomas, but gross-total resection is difficult to achieve in all cases. NF adenomas overexpress folate receptor alpha (FRα). OBJECTIVE To test the hypothesis that we could target FRα for highly sensitive and specific intraoperative detection of NF adenomas using near-infrared (NIR) imaging. METHODS Fourteen patients with NF pituitary adenoma were infused with the folate analog NIR dye OTL38… CONTINUE READING