Folate-Equipped Nanolipoplexes Mediated Efficient Gene Transfer into Human Epithelial Cells

@inproceedings{Mornet2013FolateEquippedNM,
  title={Folate-Equipped Nanolipoplexes Mediated Efficient Gene Transfer into Human Epithelial Cells},
  author={Emmanuel Mornet and Nathalie Carmoy and C{\'e}line Alexandra Lain{\'e} and Lo{\"i}c Lemi{\`e}gre and Tony Le Gall and Isabelle Laurent and R{\'e}mi Marianowski and Claude F{\'e}rec and Pierre Lehn and Thierry Benvegnu and Tristan Montier},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of transgene expression in the targeted cells. This goal can be achieved by fine-tuning the chemical carriers and the adding specific motifs to promote cellular penetration. Our study focuses on the development… CONTINUE READING
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