Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase

@article{Kronenberg2008FolateDI,
  title={Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase},
  author={Golo Kronenberg and Christoph Harms and Robert William Sobol and Fernando Cardozo-Pelaez and Heinz G. Linhart and Benjamin Winter and Mustafa G. Balkaya and Karen Gertz and Shanna B. Gay and David P Cox and Sarah Eckart and Michael Malek Ahmadi and Georg Juckel and Gerd Kempermann and Rainer Hellweg and Reinhard Sohr and Heide H{\"o}rtnagl and Samuel H. Wilson and Rudolf Jaenisch and Matthias Endres},
  journal={The Journal of Neuroscience},
  year={2008},
  volume={28},
  pages={7219 - 7230}
}
Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficiency has been implicated in the pathogenesis of psychiatric disorders, most notably depression. We hypothesized that the pathogenic mechanisms include uracil misincorporation and, therefore, analyzed the effects of folate deficiency in mice lacking uracil DNA glycosylase (Ung−/−) versus wild-type… Expand
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Folate, DNA damage and the aging brain
  • M. Fenech
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • 2010
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The current evidence that folate deficiency and associated metabolites, such as homocysteine, may accelerate DNA damage and aging of the brain is explored and important knowledge gaps are identified. Expand
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