Folate Conjugated Double Liposomes Bearing Prednisolone and Methotrexate for Targeting Rheumatoid Arthritis

@article{Verma2019FolateCD,
  title={Folate Conjugated Double Liposomes Bearing Prednisolone and Methotrexate for Targeting Rheumatoid Arthritis},
  author={Amit K Verma and Anilkumar Jain and Ankita Tiwari and Shivani Saraf and Pritish Kumar Panda and Gopal Agrawal and Sanjay K. Jain},
  journal={Pharmaceutical Research},
  year={2019},
  volume={36},
  pages={1-13}
}
PurposeThis investigation was aimed to explore the targeting potential of folate conjugated double liposomes (fDLs) bearing combination of synergistic drugs (Prednisolone and Methotrexate) for effective management of the rheumatoid arthritis (RA).MethodsTo overcome the drawbacks of monotherapy, a combination of prednisolone (PRD) (an anti-inflammatory agent) and methotrexate (MTX) (a disease modifying anti-rheumatoid agent, DMARDs) was chosen for dual targeting approach. fDLs were prepared in… CONTINUE READING

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