Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.

@article{GarcaMiss2010FolateHI,
  title={Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.},
  author={Mar{\'i}a del Rosario Garc{\'i}a-Miss and Jos{\'e} P{\'e}rez-Mutul and Bel{\'e}m L{\'o}pez-Canul and Francisco A Sol{\'i}s-Rodr{\'i}guez and Luis Puga-Machado and Adri{\'a}n Oxt{\'e}-Cabrera and Jes{\'u}s Gurubel-Maldonado and Gloria Arankowsky-Sandoval},
  journal={Journal of psychiatric research},
  year={2010},
  volume={44 7},
  pages={441-6}
}
The methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated to high homocysteine levels and schizophrenia. Since cytokines are altered in schizophrenia and increments of homocysteine could promote an inflammatory response, it was investigated whether interleukin-6 (IL-6) and tumor necrosis factor alfa (TNFalpha) levels are modulated by the MTHFR genotype. Serum levels of TNFalpha, IL-6, B(12), homocysteine, folate and red blood cell (RBC) folate as well as the MTHFR… CONTINUE READING
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