Folate, homocysteine, and negative symptoms in schizophrenia.

  title={Folate, homocysteine, and negative symptoms in schizophrenia.},
  author={Donald C. Goff and Teodoro G Bottiglieri and Erland Arning and Vivian H Shih and Oliver Freudenreich and Anne Eden Evins and David C Henderson and Lee Baer and Joseph Coyle},
  journal={The American journal of psychiatry},
  volume={161 9},
OBJECTIVE Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients. METHOD For 91 outpatients with schizophrenia, clinical assessments were performed and serum folate, homocysteine, B(12), glycine, and serine concentrations were measured. RESULTS Serum folate concentrations were significantly lower… CONTINUE READING