Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.

@article{Hornung2004FolateHA,
  title={Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.},
  author={Nete Hornung and Torkell Ellingsen and Kristian Stengaard-Pedersen and J{\o}rgen Hjelm Poulsen},
  journal={The Journal of rheumatology},
  year={2004},
  volume={31 12},
  pages={
          2374-81
        }
}
OBJECTIVE To investigate the effect of methotrexate (MTX) treatment of rheumatoid arthritis (RA) on folate metabolism, and to determine the effect of low dose folic acid on toxicity, efficacy, and folate status. METHODS A 52-week prospective study of 81 patients with RA treated with MTX and self-administered low dose folic acid; 38 patients were included prior to MTX therapy, 33 patients continued established MTX therapy, and 10 patients were excluded. Drug efficacy and side effects were… CONTINUE READING

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