Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.

Abstract

Glucocorticoids (GCs) induce surfactant synthesis in the late foetal lung. Deficient GC action causes respiratory distress syndrome (RDS). 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone), thus amplifying intracellular GC action. Reduction or loss of… (More)

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Cite this paper

@article{Hundertmark2002FoetalLM, title={Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.}, author={S Hundertmark and Alisa Dill and Andreas D. Ebert and Bernd Zimmermann and Yuri V. Kotelevtsev and J J Mullins and Jonathan R Seckl}, journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme}, year={2002}, volume={34 10}, pages={545-9} }