Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus

@article{Douar1997FoetalGD,
  title={Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus},
  author={A M Douar and S Adebakin and Michael Themis and Andr{\'e}a Pavirani and Terry Cook and Charles Coutelle},
  journal={Gene Therapy},
  year={1997},
  volume={4},
  pages={883-890}
}
With the aim of developing foetal gene therapy for cystic fibrosis, we have investigated the possibility of gene targeting to the mouse foetus with two different viral vector systems and at different times of gestation. We report here that recombinant retrovirus producing cells administered into the intra-amniotic cavity of mid- to late-gestation mouse MF1… CONTINUE READING