Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.

@article{Chen2002FocusedLA,
  title={Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.},
  author={Li Chieh Chen and Richard V Trilles and Dorota Miklowski and Tai-Nan Huang and David Spotts Fry and Robert Campbell and Karen Rowan and Virginia Schwinge and Jefferson W Tilley},
  journal={Bioorganic & medicinal chemistry letters},
  year={2002},
  volume={12 12},
  pages={
          1679-82
        }
}

• Li Chieh Chen, Richard V Trilles, +6 authors Jefferson W Tilley
• Published in Bioorganic & medicinal chemistry letters 2002

A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists characterized by the N-(alpha-phenylcyclopentanoyl- and the N-(2,6-dimethylbenzoyl)-derivatives 60 and 64. 

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