Focused Specificity of Intestinal Th17 Cells towards Commensal Bacterial Antigens

Abstract

T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis. They are most abundant in the small intestine lamina propria, where their presence requires colonization of mice with microbiota. Segmented filamentous bacteria (SFB) are sufficient to induce TH17 cells and to promote TH17-dependent autoimmune disease in… (More)
DOI: 10.1038/nature13279

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